Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals in the microenvironment and escalating the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have discovered recurrent mutations in genes regulating tumor mobile-microenvironment interactions, w... https://saeedi297ajr5.wikipowell.com/user