The impairment of HMGB1 functionality results in amplified mitochondrial DNA harm. From the SCA1 mouse product, above-expression with the HMGB1 protein via an launched virus vector bearing the HMGB1 gene facilitates repair in the mitochondrial DNA destruction, ameliorates the neuropathology as well as the motor deficits, and extends the lifespan https://englandf444tdp7.aboutyoublog.com/profile